Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes

The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450...

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Detalles Bibliográficos
Autores principales: Grumaz, Christian, Vainshtein, Yevhen, Kirstahler, Philipp, Luetz, Stephan, Kittelmann, Matthias, Schroer, Kirsten, Eggimann, Fabian K., Czaja, Rico, Vogel, Andreas, Hilberath, Thomas, Worsch, Anne, Girhard, Marco, Urlacher, Vlada B., Sandberg, Marcel, Sohn, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511904/
https://www.ncbi.nlm.nih.gov/pubmed/28705965
http://dx.doi.org/10.1128/genomeA.00532-17
Descripción
Sumario:The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites.

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