Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes

The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450...

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Autores principales: Grumaz, Christian, Vainshtein, Yevhen, Kirstahler, Philipp, Luetz, Stephan, Kittelmann, Matthias, Schroer, Kirsten, Eggimann, Fabian K., Czaja, Rico, Vogel, Andreas, Hilberath, Thomas, Worsch, Anne, Girhard, Marco, Urlacher, Vlada B., Sandberg, Marcel, Sohn, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511904/
https://www.ncbi.nlm.nih.gov/pubmed/28705965
http://dx.doi.org/10.1128/genomeA.00532-17
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author Grumaz, Christian
Vainshtein, Yevhen
Kirstahler, Philipp
Luetz, Stephan
Kittelmann, Matthias
Schroer, Kirsten
Eggimann, Fabian K.
Czaja, Rico
Vogel, Andreas
Hilberath, Thomas
Worsch, Anne
Girhard, Marco
Urlacher, Vlada B.
Sandberg, Marcel
Sohn, Kai
author_facet Grumaz, Christian
Vainshtein, Yevhen
Kirstahler, Philipp
Luetz, Stephan
Kittelmann, Matthias
Schroer, Kirsten
Eggimann, Fabian K.
Czaja, Rico
Vogel, Andreas
Hilberath, Thomas
Worsch, Anne
Girhard, Marco
Urlacher, Vlada B.
Sandberg, Marcel
Sohn, Kai
author_sort Grumaz, Christian
collection PubMed
description The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites.
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spelling pubmed-55119042017-07-25 Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes Grumaz, Christian Vainshtein, Yevhen Kirstahler, Philipp Luetz, Stephan Kittelmann, Matthias Schroer, Kirsten Eggimann, Fabian K. Czaja, Rico Vogel, Andreas Hilberath, Thomas Worsch, Anne Girhard, Marco Urlacher, Vlada B. Sandberg, Marcel Sohn, Kai Genome Announc Prokaryotes The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel their gene sets encoding promising cytochrome P450 monooxygenases associated with the generation of drug metabolites. American Society for Microbiology 2017-07-13 /pmc/articles/PMC5511904/ /pubmed/28705965 http://dx.doi.org/10.1128/genomeA.00532-17 Text en Copyright © 2017 Grumaz et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Prokaryotes
Grumaz, Christian
Vainshtein, Yevhen
Kirstahler, Philipp
Luetz, Stephan
Kittelmann, Matthias
Schroer, Kirsten
Eggimann, Fabian K.
Czaja, Rico
Vogel, Andreas
Hilberath, Thomas
Worsch, Anne
Girhard, Marco
Urlacher, Vlada B.
Sandberg, Marcel
Sohn, Kai
Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title_full Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title_fullStr Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title_full_unstemmed Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title_short Draft Genome Sequences of Three Actinobacteria Strains Presenting New Candidate Organisms with High Potentials for Specific P450 Cytochromes
title_sort draft genome sequences of three actinobacteria strains presenting new candidate organisms with high potentials for specific p450 cytochromes
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511904/
https://www.ncbi.nlm.nih.gov/pubmed/28705965
http://dx.doi.org/10.1128/genomeA.00532-17
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