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Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease

The association between dopamine neuron loss and functional change in the striatocortical network was analyzed in 31 patients with Parkinson’s disease (PD) [mean disease duration 4.03 ± 4.20 years; Hoehn and Yahr (HY) stage 2.2 ± 1.2] and 37 age-matched normal control subjects. We performed (99m)Tc-...

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Autores principales: Lin, Wei-Che, Chen, Hsiu-Ling, Hsu, Tun-Wei, Hsu, Chien-Chin, Huang, Yung-Cheng, Tsai, Nai-Wen, Lu, Cheng-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511968/
https://www.ncbi.nlm.nih.gov/pubmed/28769862
http://dx.doi.org/10.3389/fneur.2017.00323
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author Lin, Wei-Che
Chen, Hsiu-Ling
Hsu, Tun-Wei
Hsu, Chien-Chin
Huang, Yung-Cheng
Tsai, Nai-Wen
Lu, Cheng-Hsien
author_facet Lin, Wei-Che
Chen, Hsiu-Ling
Hsu, Tun-Wei
Hsu, Chien-Chin
Huang, Yung-Cheng
Tsai, Nai-Wen
Lu, Cheng-Hsien
author_sort Lin, Wei-Che
collection PubMed
description The association between dopamine neuron loss and functional change in the striatocortical network was analyzed in 31 patients with Parkinson’s disease (PD) [mean disease duration 4.03 ± 4.20 years; Hoehn and Yahr (HY) stage 2.2 ± 1.2] and 37 age-matched normal control subjects. We performed (99m)Tc-TRODAT-1 SPECT/CT imaging to detect neuron losses and resting-state functional magnetic resonance imaging to detect functional changes. Mean striatal dopamine transporter binding ratios were determined by region of interest analysis. The functional connectivity correlation coefficient (fc-cc) was determined in six striatal subregions, and interactions between these binding ratios and the striatocortical fc-cc values were analyzed. The PD patients had significant functional network alterations in all striatal subregions. Lower striatal dopamine transporter binding correlated significantly with lower fc-cc values in the superior medial frontal (SMF) lobe and superior frontal lobe and higher fc-cc values in the cerebellum and parahippocampus. The difference in fc-cc between the ventral inferior striatum and SMF lobe was significantly correlated with increased disease duration (r = –0.533, P = 0.004), higher HY stage (r = –0.431, P = 0.020), and lower activities of daily living score (r = 0.369, P = 0.049). The correlation of frontostriatal network changes with clinical manifestations suggests that fc-cc may serve as a surrogate marker of disease progression.
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spelling pubmed-55119682017-08-02 Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease Lin, Wei-Che Chen, Hsiu-Ling Hsu, Tun-Wei Hsu, Chien-Chin Huang, Yung-Cheng Tsai, Nai-Wen Lu, Cheng-Hsien Front Neurol Neuroscience The association between dopamine neuron loss and functional change in the striatocortical network was analyzed in 31 patients with Parkinson’s disease (PD) [mean disease duration 4.03 ± 4.20 years; Hoehn and Yahr (HY) stage 2.2 ± 1.2] and 37 age-matched normal control subjects. We performed (99m)Tc-TRODAT-1 SPECT/CT imaging to detect neuron losses and resting-state functional magnetic resonance imaging to detect functional changes. Mean striatal dopamine transporter binding ratios were determined by region of interest analysis. The functional connectivity correlation coefficient (fc-cc) was determined in six striatal subregions, and interactions between these binding ratios and the striatocortical fc-cc values were analyzed. The PD patients had significant functional network alterations in all striatal subregions. Lower striatal dopamine transporter binding correlated significantly with lower fc-cc values in the superior medial frontal (SMF) lobe and superior frontal lobe and higher fc-cc values in the cerebellum and parahippocampus. The difference in fc-cc between the ventral inferior striatum and SMF lobe was significantly correlated with increased disease duration (r = –0.533, P = 0.004), higher HY stage (r = –0.431, P = 0.020), and lower activities of daily living score (r = 0.369, P = 0.049). The correlation of frontostriatal network changes with clinical manifestations suggests that fc-cc may serve as a surrogate marker of disease progression. Frontiers Media S.A. 2017-07-17 /pmc/articles/PMC5511968/ /pubmed/28769862 http://dx.doi.org/10.3389/fneur.2017.00323 Text en Copyright © 2017 Lin, Chen, Hsu, Hsu, Huang, Tsai and Lu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lin, Wei-Che
Chen, Hsiu-Ling
Hsu, Tun-Wei
Hsu, Chien-Chin
Huang, Yung-Cheng
Tsai, Nai-Wen
Lu, Cheng-Hsien
Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title_full Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title_fullStr Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title_full_unstemmed Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title_short Correlation between Dopamine Transporter Degradation and Striatocortical Network Alteration in Parkinson’s Disease
title_sort correlation between dopamine transporter degradation and striatocortical network alteration in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511968/
https://www.ncbi.nlm.nih.gov/pubmed/28769862
http://dx.doi.org/10.3389/fneur.2017.00323
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