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Redox regulation of proteasome function
Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512181/ https://www.ncbi.nlm.nih.gov/pubmed/28715730 http://dx.doi.org/10.1016/j.redox.2017.07.005 |
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author | Lefaki, Maria Papaevgeniou, Nikoletta Chondrogianni, Niki |
author_facet | Lefaki, Maria Papaevgeniou, Nikoletta Chondrogianni, Niki |
author_sort | Lefaki, Maria |
collection | PubMed |
description | Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations. This short review summarizes the effects of oxidative stress on proteasome status while it also recapitulates conditions and processes where redox alterations signal changes to proteasome expression, assembly and function. |
format | Online Article Text |
id | pubmed-5512181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-55121812017-07-26 Redox regulation of proteasome function Lefaki, Maria Papaevgeniou, Nikoletta Chondrogianni, Niki Redox Biol Short Communication Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations. This short review summarizes the effects of oxidative stress on proteasome status while it also recapitulates conditions and processes where redox alterations signal changes to proteasome expression, assembly and function. Elsevier 2017-07-06 /pmc/articles/PMC5512181/ /pubmed/28715730 http://dx.doi.org/10.1016/j.redox.2017.07.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Communication Lefaki, Maria Papaevgeniou, Nikoletta Chondrogianni, Niki Redox regulation of proteasome function |
title | Redox regulation of proteasome function |
title_full | Redox regulation of proteasome function |
title_fullStr | Redox regulation of proteasome function |
title_full_unstemmed | Redox regulation of proteasome function |
title_short | Redox regulation of proteasome function |
title_sort | redox regulation of proteasome function |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512181/ https://www.ncbi.nlm.nih.gov/pubmed/28715730 http://dx.doi.org/10.1016/j.redox.2017.07.005 |
work_keys_str_mv | AT lefakimaria redoxregulationofproteasomefunction AT papaevgeniounikoletta redoxregulationofproteasomefunction AT chondrogianniniki redoxregulationofproteasomefunction |