p15(Ink4b) Loss of Expression by Promoter Hypermethylation Adds to Leukemogenesis and Confers a Poor Prognosis in Acute Promyelocytic Leukemia Patients

PURPOSE: The p15(Ink4b) gene exerts its influence as an inhibitor of cyclin-dependent kinases and is frequently associated with hematological malignancies. Inactivation of this gene through DNA methylation has been found to be the most prevalent epigenetic alteration reported, with a high frequency...

Descripción completa

Detalles Bibliográficos
Autores principales: Baba, Shahid M., Azad, Niyaz A., Shah, Zafar A., Dil-Afroze, Pandith, Arshad A., Jan, Aleem, Aziz, Sheikh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512385/
https://www.ncbi.nlm.nih.gov/pubmed/28052659
http://dx.doi.org/10.4143/crt.2016.108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512385/
https://www.ncbi.nlm.nih.gov/pubmed/28052659
http://dx.doi.org/10.4143/crt.2016.108

Ejemplares similares