Cargando…
Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae
Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serol...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512482/ https://www.ncbi.nlm.nih.gov/pubmed/28628455 http://dx.doi.org/10.3201/eid2307.161858 |
_version_ | 1783250486584934400 |
---|---|
author | Marrie, Thomas J. Tyrrell, Gregory J. Majumdar, Sumit R. Eurich, Dean T. |
author_facet | Marrie, Thomas J. Tyrrell, Gregory J. Majumdar, Sumit R. Eurich, Dean T. |
author_sort | Marrie, Thomas J. |
collection | PubMed |
description | Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000–2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression. A total of 355 of 3,251 patients with IPD were co-infected with HCV. The in-hospital mortality rate was higher for IPD patients infected with HCV. Prevalence of most IPD-related complications (e.g., cellulitis, acute kidney injury, mechanical ventilation) was also higher in HCV-infected patients. Infection with HCV is common in patients with IPD, and HCV is independently associated with an increased risk for serious illness and death. |
format | Online Article Text |
id | pubmed-5512482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-55124822017-07-19 Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae Marrie, Thomas J. Tyrrell, Gregory J. Majumdar, Sumit R. Eurich, Dean T. Emerg Infect Dis Research Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000–2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression. A total of 355 of 3,251 patients with IPD were co-infected with HCV. The in-hospital mortality rate was higher for IPD patients infected with HCV. Prevalence of most IPD-related complications (e.g., cellulitis, acute kidney injury, mechanical ventilation) was also higher in HCV-infected patients. Infection with HCV is common in patients with IPD, and HCV is independently associated with an increased risk for serious illness and death. Centers for Disease Control and Prevention 2017-07 /pmc/articles/PMC5512482/ /pubmed/28628455 http://dx.doi.org/10.3201/eid2307.161858 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Marrie, Thomas J. Tyrrell, Gregory J. Majumdar, Sumit R. Eurich, Dean T. Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title | Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title_full | Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title_fullStr | Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title_full_unstemmed | Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title_short | Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae |
title_sort | concurrent infection with hepatitis c virus and streptococcus pneumoniae |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512482/ https://www.ncbi.nlm.nih.gov/pubmed/28628455 http://dx.doi.org/10.3201/eid2307.161858 |
work_keys_str_mv | AT marriethomasj concurrentinfectionwithhepatitiscvirusandstreptococcuspneumoniae AT tyrrellgregoryj concurrentinfectionwithhepatitiscvirusandstreptococcuspneumoniae AT majumdarsumitr concurrentinfectionwithhepatitiscvirusandstreptococcuspneumoniae AT eurichdeant concurrentinfectionwithhepatitiscvirusandstreptococcuspneumoniae |