Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency

We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–in...

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Detalles Bibliográficos
Autores principales: Asakura, Takanori, Namkoong, Ho, Sakagami, Takuro, Hasegawa, Naoki, Ohkusu, Kiyofumi, Nakamura, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512497/
https://www.ncbi.nlm.nih.gov/pubmed/28628454
http://dx.doi.org/10.3201/eid2307.161677
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author Asakura, Takanori
Namkoong, Ho
Sakagami, Takuro
Hasegawa, Naoki
Ohkusu, Kiyofumi
Nakamura, Akira
author_facet Asakura, Takanori
Namkoong, Ho
Sakagami, Takuro
Hasegawa, Naoki
Ohkusu, Kiyofumi
Nakamura, Akira
author_sort Asakura, Takanori
collection PubMed
description We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–interferon-γ autoantibodies, in addition to HIV infection, can lead to disseminated nontuberculous mycobacterial infection.
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spelling pubmed-55124972017-07-19 Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency Asakura, Takanori Namkoong, Ho Sakagami, Takuro Hasegawa, Naoki Ohkusu, Kiyofumi Nakamura, Akira Emerg Infect Dis Research Letter We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–interferon-γ autoantibodies, in addition to HIV infection, can lead to disseminated nontuberculous mycobacterial infection. Centers for Disease Control and Prevention 2017-07 /pmc/articles/PMC5512497/ /pubmed/28628454 http://dx.doi.org/10.3201/eid2307.161677 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Asakura, Takanori
Namkoong, Ho
Sakagami, Takuro
Hasegawa, Naoki
Ohkusu, Kiyofumi
Nakamura, Akira
Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title_full Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title_fullStr Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title_full_unstemmed Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title_short Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency
title_sort disseminated mycobacterium genavense infection in patient with adult-onset immunodeficiency
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512497/
https://www.ncbi.nlm.nih.gov/pubmed/28628454
http://dx.doi.org/10.3201/eid2307.161677
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