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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood. Here we show using the inositol polyphosphate 5′-phosphatase E (INPP5E) and the GTP-binding protein (Rheb) that ca...

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Detalles Bibliográficos
Autores principales:	Fansa, Eyad Kalawy, Kösling, Stefanie Kristine, Zent, Eldar, Wittinghofer, Alfred, Ismail, Shehab
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512577/ https://www.ncbi.nlm.nih.gov/pubmed/27063844 http://dx.doi.org/10.1038/ncomms11366

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