Computational design of trimeric influenza neutralizing proteins targeting the hemagglutinin receptor binding site

Many viral surface glycoproteins and cell surface receptors are homo-oligomers(1-4), and hence can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The adaptive immune system cannot generally...

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Detalles Bibliográficos
Autores principales: Strauch, EM, Bernard, SM, La, D, Bohn, AJ, Lee, PS, Anderson, CE, Nieusma, T, Holstein, CA, Garcia, NK, Hooper, KA, Ravichandran, R, Nelson, JW, Sheffler, W, Bloom, JD, Lee, KK, Ward, AB, Yager, P, Fuller, DH, Wilson, IA, Baker, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512607/
https://www.ncbi.nlm.nih.gov/pubmed/28604661
http://dx.doi.org/10.1038/nbt.3907

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