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Analysis of correlated mutations in Ras G-domain
Ras GTPases are most prevalent proto-oncogenes in human cancer. Mutations in Ras remain untreatable more than three decades after the initial discovery. At the amino acid level, some residues under physical or functional constraints exhibit correlated mutations also known as coevolving/covariant res...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Biomedical Informatics
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512854/ https://www.ncbi.nlm.nih.gov/pubmed/28729758 http://dx.doi.org/10.6026/97320630013174 |