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Designing of a penta-peptide against drug resistant E. coli
Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits bet...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512857/ https://www.ncbi.nlm.nih.gov/pubmed/28729761 http://dx.doi.org/10.6026/97320630013192 |
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author | Nagra, Sachin Kumar, Deepak Bhattacharyya, Rajasri Banerjee, Dibyajyoti Mukherjee, Tapan |
author_facet | Nagra, Sachin Kumar, Deepak Bhattacharyya, Rajasri Banerjee, Dibyajyoti Mukherjee, Tapan |
author_sort | Nagra, Sachin |
collection | PubMed |
description | Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept. |
format | Online Article Text |
id | pubmed-5512857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-55128572017-07-20 Designing of a penta-peptide against drug resistant E. coli Nagra, Sachin Kumar, Deepak Bhattacharyya, Rajasri Banerjee, Dibyajyoti Mukherjee, Tapan Bioinformation Hypothesis Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept. Biomedical Informatics 2017-06-30 /pmc/articles/PMC5512857/ /pubmed/28729761 http://dx.doi.org/10.6026/97320630013192 Text en © 2017 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Hypothesis Nagra, Sachin Kumar, Deepak Bhattacharyya, Rajasri Banerjee, Dibyajyoti Mukherjee, Tapan Designing of a penta-peptide against drug resistant E. coli |
title | Designing of a penta-peptide against drug resistant E. coli |
title_full | Designing of a penta-peptide against drug resistant E. coli |
title_fullStr | Designing of a penta-peptide against drug resistant E. coli |
title_full_unstemmed | Designing of a penta-peptide against drug resistant E. coli |
title_short | Designing of a penta-peptide against drug resistant E. coli |
title_sort | designing of a penta-peptide against drug resistant e. coli |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512857/ https://www.ncbi.nlm.nih.gov/pubmed/28729761 http://dx.doi.org/10.6026/97320630013192 |
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