Designing of a penta-peptide against drug resistant E. coli

Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits bet...

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Detalles Bibliográficos
Autores principales: Nagra, Sachin, Kumar, Deepak, Bhattacharyya, Rajasri, Banerjee, Dibyajyoti, Mukherjee, Tapan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2017
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512857/
https://www.ncbi.nlm.nih.gov/pubmed/28729761
http://dx.doi.org/10.6026/97320630013192
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author Nagra, Sachin
Kumar, Deepak
Bhattacharyya, Rajasri
Banerjee, Dibyajyoti
Mukherjee, Tapan
author_facet Nagra, Sachin
Kumar, Deepak
Bhattacharyya, Rajasri
Banerjee, Dibyajyoti
Mukherjee, Tapan
author_sort Nagra, Sachin
collection PubMed
description Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept.
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spelling pubmed-55128572017-07-20 Designing of a penta-peptide against drug resistant E. coli Nagra, Sachin Kumar, Deepak Bhattacharyya, Rajasri Banerjee, Dibyajyoti Mukherjee, Tapan Bioinformation Hypothesis Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept. Biomedical Informatics 2017-06-30 /pmc/articles/PMC5512857/ /pubmed/28729761 http://dx.doi.org/10.6026/97320630013192 Text en © 2017 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Hypothesis
Nagra, Sachin
Kumar, Deepak
Bhattacharyya, Rajasri
Banerjee, Dibyajyoti
Mukherjee, Tapan
Designing of a penta-peptide against drug resistant E. coli
title Designing of a penta-peptide against drug resistant E. coli
title_full Designing of a penta-peptide against drug resistant E. coli
title_fullStr Designing of a penta-peptide against drug resistant E. coli
title_full_unstemmed Designing of a penta-peptide against drug resistant E. coli
title_short Designing of a penta-peptide against drug resistant E. coli
title_sort designing of a penta-peptide against drug resistant e. coli
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512857/
https://www.ncbi.nlm.nih.gov/pubmed/28729761
http://dx.doi.org/10.6026/97320630013192
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