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A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite
Hydroxyapatite (HA) is a widely studied biomaterial for its similar chemical composition to bone and its osteoconductive properties. The crystal structure of HA is flexible, allowing for a wide range of substitutions which can alter bioactivity, biodegradation, and mechanical properties of the subst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512915/ https://www.ncbi.nlm.nih.gov/pubmed/28793572 http://dx.doi.org/10.3390/ma8095308 |
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author | Zilm, Michael Thomson, Seamus D. Wei, Mei |
author_facet | Zilm, Michael Thomson, Seamus D. Wei, Mei |
author_sort | Zilm, Michael |
collection | PubMed |
description | Hydroxyapatite (HA) is a widely studied biomaterial for its similar chemical composition to bone and its osteoconductive properties. The crystal structure of HA is flexible, allowing for a wide range of substitutions which can alter bioactivity, biodegradation, and mechanical properties of the substituted apatite. The thermal stability of a substituted apatite is an indication of its biodegradation in vivo. In this study, we investigated the thermal stability and mechanical properties of manganese-substituted hydroxyapatite (MnHA) as it is reported that manganese can enhance cell attachment compared to pure HA. Pure HA and MnHA pellets were sintered over the following temperature ranges: 900 to 1300 °C and 700 to 1300 °C respectively. The sintered pellets were characterized via density measurements, mechanical testing, X-ray diffraction, and field emission electron microscopy. It was found that MnHA was less stable than HA decomposing around 800 °C compared to 1200 °C for HA. The flexural strength of MnHA was weaker than HA due to the decomposition of MnHA at a significantly lower temperature of 800 °C compared to 1100 °C for HA. The low thermal stability of MnHA suggests that a faster in vivo dissolution rate compared to pure HA is expected. |
format | Online Article Text |
id | pubmed-5512915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55129152017-07-28 A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite Zilm, Michael Thomson, Seamus D. Wei, Mei Materials (Basel) Article Hydroxyapatite (HA) is a widely studied biomaterial for its similar chemical composition to bone and its osteoconductive properties. The crystal structure of HA is flexible, allowing for a wide range of substitutions which can alter bioactivity, biodegradation, and mechanical properties of the substituted apatite. The thermal stability of a substituted apatite is an indication of its biodegradation in vivo. In this study, we investigated the thermal stability and mechanical properties of manganese-substituted hydroxyapatite (MnHA) as it is reported that manganese can enhance cell attachment compared to pure HA. Pure HA and MnHA pellets were sintered over the following temperature ranges: 900 to 1300 °C and 700 to 1300 °C respectively. The sintered pellets were characterized via density measurements, mechanical testing, X-ray diffraction, and field emission electron microscopy. It was found that MnHA was less stable than HA decomposing around 800 °C compared to 1200 °C for HA. The flexural strength of MnHA was weaker than HA due to the decomposition of MnHA at a significantly lower temperature of 800 °C compared to 1100 °C for HA. The low thermal stability of MnHA suggests that a faster in vivo dissolution rate compared to pure HA is expected. MDPI 2015-09-18 /pmc/articles/PMC5512915/ /pubmed/28793572 http://dx.doi.org/10.3390/ma8095308 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zilm, Michael Thomson, Seamus D. Wei, Mei A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title | A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title_full | A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title_fullStr | A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title_full_unstemmed | A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title_short | A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite |
title_sort | comparative study of the sintering behavior of pure and manganese-substituted hydroxyapatite |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512915/ https://www.ncbi.nlm.nih.gov/pubmed/28793572 http://dx.doi.org/10.3390/ma8095308 |
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