Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

BACKGROUND: Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors have been successfully designed, no comprehensive assessment of affinity and s...

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Detalles Bibliográficos
Autores principales: Wong, Margaret L., Murphy, Jason, Harrington, Edmund, Gower, Carrie M., Jain, Rishi K., Schirle, Markus, Thomas, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513037/
https://www.ncbi.nlm.nih.gov/pubmed/28725163
http://dx.doi.org/10.1186/s12953-017-0125-1

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