SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model

A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as Fos and Egr1. We employed the mouse pilocarpine model to an...

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Detalles Bibliográficos
Autores principales: Lösing, Pascal, Niturad, Cristina Elena, Harrer, Merle, Reckendorf, Christopher Meyer zu, Schatz, Theresa, Sinske, Daniela, Lerche, Holger, Maljevic, Snezana, Knöll, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513048/
https://www.ncbi.nlm.nih.gov/pubmed/28716058
http://dx.doi.org/10.1186/s13041-017-0310-2

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