Cargando…

A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

BACKGROUND: CAD-31 is an Alzheimer’s disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/PS1ΔE9 AD mice. To move CAD-31 toward the clinic, experiments were undertaken t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daugherty, Daniel, Goldberg, Joshua, Fischer, Wolfgang, Dargusch, Richard, Maher, Pamela, Schubert, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513091/ https://www.ncbi.nlm.nih.gov/pubmed/28709449 http://dx.doi.org/10.1186/s13195-017-0277-3

Ejemplares similares

Geroprotective effects of Alzheimer’s disease drug candidates
por: Kepchia, Devin, et al.
Publicado: (2021)

The mitochondrial ATP synthase is a shared drug target for aging and dementia
por: Goldberg, Joshua, et al.
Publicado: (2018)

CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease
por: Ates, Gamze, et al.
Publicado: (2020)

A comprehensive multiomics approach toward understanding the relationship between aging and dementia
por: Currais, Antonio, et al.
Publicado: (2015)

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease
por: Chen, Qi, et al.
Publicado: (2011)

Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa
por: Fischer, Wolfgang, et al.
Publicado: (2018)

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice
por: Currais, Antonio, et al.
Publicado: (2014)

Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
por: Kepchia, Devin, et al.
Publicado: (2020)

The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice
por: Zahid, Saadia, et al.
Publicado: (2023)

Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes
por: Maher, Pamela, et al.
Publicado: (2011)

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
por: Prior, Marguerite, et al.
Publicado: (2013)

Targeting of intracellular Ca(2+) stores as a therapeutic strategy against age-related neurotoxicities
por: Goldberg, Joshua, et al.
Publicado: (2020)

A novel fatty acid metabolism-related gene prognostic signature and candidate drugs for patients with hepatocellular carcinoma
por: Yang, Jingze, et al.
Publicado: (2023)

Targeting fatty acid metabolism in glioblastoma
por: Miska, Jason, et al.
Publicado: (2023)

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
por: Bayraktar, Abdulahad, et al.
Publicado: (2023)

Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates
por: Prikhodko, Veronika A., et al.
Publicado: (2022)

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease
por: Fang, Jiansong, et al.
Publicado: (2022)

2-Hydroxylated fatty acids as candidates of novel drugs to promote chemosensitivity of gastric cancer
por: Tsuboi, Kazuhito
Publicado: (2019)

Improved Candidate Drug Mining for Alzheimer's Disease
por: Cheng, Yu-Huei, et al.
Publicado: (2014)

Drug candidates in clinical trials for Alzheimer’s disease
por: Hung, Shih-Ya, et al.
Publicado: (2017)

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease
por: Miziak, Barbara, et al.
Publicado: (2021)

Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy
por: Lamie, Phoebe F., et al.
Publicado: (2022)

The prognosis of bladder cancer is affected by fatty acid metabolism, inflammation, and hypoxia
por: Xiao, Yu, et al.
Publicado: (2022)

A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism
por: Lage-Rupprecht, Vanessa, et al.
Publicado: (2022)

Fatty Acid Composition and Metabolism in Leishmania Parasite Species: Potential Biomarkers or Drug Targets for Leishmaniasis?
por: Leroux, Marine, et al.
Publicado: (2023)

Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids
por: Ye, Zhenhong, et al.
Publicado: (2020)

Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia
por: Maher, Michael, et al.
Publicado: (2018)

Association between Polyunsaturated Fatty Acid Profile and Bronchial Inflammation in Bronchiolitis Obliterans
por: Jerkic, Silvija P., et al.
Publicado: (2023)

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates
por: Jain, Surbhi, et al.
Publicado: (2022)

Fatty acid metabolism and drug resistance to EZH2 inhibition
por: Wang, Yemin
Publicado: (2022)

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis
por: Quinonez, Camila G., et al.
Publicado: (2022)

Polyunsaturated fatty acids, inflammation, and metabolic syndrome in South Asian Americans in Maryland
por: Khan, Saira A., et al.
Publicado: (2018)

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates
por: Vargas, D. M., et al.
Publicado: (2018)

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease
por: Fancellu, Gaia, et al.
Publicado: (2019)

Novel drug candidates targeting Alzheimer’s disease: ethical challenges with identifying the relevant patient population
por: Gustavsson, Erik, et al.
Publicado: (2021)

Identification of Prognostic Fatty Acid Metabolism lncRNAs and Potential Molecular Targeting Drugs in Uveal Melanoma
por: Xu, Yang, et al.
Publicado: (2022)

MicroRNAs as Candidate Biomarkers for Alzheimer’s Disease
por: Kanach, Colin, et al.
Publicado: (2021)

Pyroptosis as a candidate therapeutic target for Alzheimer’s disease
por: Huang, Yuehua, et al.
Publicado: (2022)

Regulation of Antioxidant Metabolism by Translation Initiation Factor 2α
por: Tan, Shirlee, et al.
Publicado: (2001)

Neurotrophic and Neuroprotective Actions of (−)- and (+)-Phenserine, Candidate Drugs for Alzheimer’s Disease
por: Lilja, Anna M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_j66aq9c3bet2qrkd56mi2rksse