PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function K(IR)2.1 channels, but increases channel protein expression

BACKGROUND: The inward rectifier potassium current I(K1) contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased I(K1), short QT syndrome type 3 and congenital atrial fibri...

Descripción completa

Detalles Bibliográficos
Autores principales: Ji, Yuan, Veldhuis, Marlieke G., Zandvoort, Jantien, Romunde, Fee L., Houtman, Marien J. C., Duran, Karen, van Haaften, Gijs, Zangerl-Plessl, Eva-Maria, Takanari, Hiroki, Stary-Weinzinger, Anna, van der Heyden, Marcel A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513211/
https://www.ncbi.nlm.nih.gov/pubmed/28711067
http://dx.doi.org/10.1186/s12929-017-0352-x

Ejemplares similares

Ejemplares similares