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Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study
BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513334/ https://www.ncbi.nlm.nih.gov/pubmed/28705180 http://dx.doi.org/10.1186/s12879-017-2572-9 |
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author | Ai, Junhong Xie, Zhengde Liu, Gang Chen, Zongbo Yang, Yong Li, Yuning Chen, Jing Zheng, Guo Shen, Kunling |
author_facet | Ai, Junhong Xie, Zhengde Liu, Gang Chen, Zongbo Yang, Yong Li, Yuning Chen, Jing Zheng, Guo Shen, Kunling |
author_sort | Ai, Junhong |
collection | PubMed |
description | BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5.88 ± 3.60 years and 6.39 ± 3.57 years, respectively. Real-time reverse transcription PCR and multiplex PCR were used to detect human enteroviruses and herpes viruses in cerebrospinal fluid (CSF) of patients with encephalitis or meningitis. The enzyme-linked immune absorbent assay (ELISA) was used for detecting IgM antibody against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients’ hospitalization. RESULTS: The etiology of viral encephalitis was confirmed in 52.5% patients. The primary pathogen was human enteroviruses (27.7%) in viral encephalitis. The incidence of sequelae and the fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The etiology of viral meningitis was identified in 42.8% cases. The leading pathogen was also human enteroviruses (37.7%) in viral meningitis. The prognosis of viral meningitis was favorable with only 0.7% patients had neurological sequelae. CONCLUSIONS: Human enteroviruses were the leading cause both in acute viral encephalitis and viral meningitis in children. The incidence of sequelae and fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The prognosis of viral meningitis was favorable compared to viral encephalitis. |
format | Online Article Text |
id | pubmed-5513334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55133342017-07-19 Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study Ai, Junhong Xie, Zhengde Liu, Gang Chen, Zongbo Yang, Yong Li, Yuning Chen, Jing Zheng, Guo Shen, Kunling BMC Infect Dis Research Article BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5.88 ± 3.60 years and 6.39 ± 3.57 years, respectively. Real-time reverse transcription PCR and multiplex PCR were used to detect human enteroviruses and herpes viruses in cerebrospinal fluid (CSF) of patients with encephalitis or meningitis. The enzyme-linked immune absorbent assay (ELISA) was used for detecting IgM antibody against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients’ hospitalization. RESULTS: The etiology of viral encephalitis was confirmed in 52.5% patients. The primary pathogen was human enteroviruses (27.7%) in viral encephalitis. The incidence of sequelae and the fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The etiology of viral meningitis was identified in 42.8% cases. The leading pathogen was also human enteroviruses (37.7%) in viral meningitis. The prognosis of viral meningitis was favorable with only 0.7% patients had neurological sequelae. CONCLUSIONS: Human enteroviruses were the leading cause both in acute viral encephalitis and viral meningitis in children. The incidence of sequelae and fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The prognosis of viral meningitis was favorable compared to viral encephalitis. BioMed Central 2017-07-14 /pmc/articles/PMC5513334/ /pubmed/28705180 http://dx.doi.org/10.1186/s12879-017-2572-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Ai, Junhong Xie, Zhengde Liu, Gang Chen, Zongbo Yang, Yong Li, Yuning Chen, Jing Zheng, Guo Shen, Kunling Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title | Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title_full | Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title_fullStr | Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title_full_unstemmed | Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title_short | Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study |
title_sort | etiology and prognosis of acute viral encephalitis and meningitis in chinese children: a multicentre prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513334/ https://www.ncbi.nlm.nih.gov/pubmed/28705180 http://dx.doi.org/10.1186/s12879-017-2572-9 |
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