Peto’s Paradox: how has evolution solved the problem of cancer prevention?

The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the esse...

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Detalles Bibliográficos
Autores principales: Tollis, Marc, Boddy, Amy M., Maley, Carlo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Question and Answer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513346/
https://www.ncbi.nlm.nih.gov/pubmed/28705195
http://dx.doi.org/10.1186/s12915-017-0401-7
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author Tollis, Marc
Boddy, Amy M.
Maley, Carlo C.
author_facet Tollis, Marc
Boddy, Amy M.
Maley, Carlo C.
author_sort Tollis, Marc
collection PubMed
description The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto’s Paradox. We discuss what is known about Peto’s Paradox and provide hints of what is yet to be discovered.
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spelling pubmed-55133462017-07-19 Peto’s Paradox: how has evolution solved the problem of cancer prevention? Tollis, Marc Boddy, Amy M. Maley, Carlo C. BMC Biol Question and Answer The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto’s Paradox. We discuss what is known about Peto’s Paradox and provide hints of what is yet to be discovered. BioMed Central 2017-07-13 /pmc/articles/PMC5513346/ /pubmed/28705195 http://dx.doi.org/10.1186/s12915-017-0401-7 Text en © Maley et al. 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Question and Answer
Tollis, Marc
Boddy, Amy M.
Maley, Carlo C.
Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title_full Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title_fullStr Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title_full_unstemmed Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title_short Peto’s Paradox: how has evolution solved the problem of cancer prevention?
title_sort peto’s paradox: how has evolution solved the problem of cancer prevention?
topic Question and Answer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513346/
https://www.ncbi.nlm.nih.gov/pubmed/28705195
http://dx.doi.org/10.1186/s12915-017-0401-7
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