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Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study

BACKGROUND: Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and pe...

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Autores principales: Henninger, Josefin, Rawshani, Araz, Hammarstedt, Ann, Eliasson, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513347/
https://www.ncbi.nlm.nih.gov/pubmed/28705209
http://dx.doi.org/10.1186/s12902-017-0191-5
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author Henninger, Josefin
Rawshani, Araz
Hammarstedt, Ann
Eliasson, Björn
author_facet Henninger, Josefin
Rawshani, Araz
Hammarstedt, Ann
Eliasson, Björn
author_sort Henninger, Josefin
collection PubMed
description BACKGROUND: Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and persons with no known family history of T2D (non-FDR). METHODS: In 200 FDR and 73 non-FDR, we compared anthropometrics, glucose tolerance status, different measurements of insulin secretion, insulin resistance, as well as blood lipids and other blood analyses. RESULTS: In the FDR group, 30 individuals had impaired glucose tolerance or T2D. Among the non-FDR, two individuals had impaired glucose tolerance. In unadjusted data, the FDR were older, had stronger heredity for coronary heart disease, lower body mass index and weight, higher OGTT plasma glucose concentrations, and impaired insulin secretion (all p < 0.05). Using propensity score, we matched the groups, resulting in significantly stronger heredity of coronary heart disease, higher OGTT plasma glucose at 60 and 90 min, larger glucose area under curve during the OGTT and higher serum creatinine among the FDR. Using least squares means, OGTT glucose at 60 and 120 min, as well as the area under curve, and OGTT insulin levels at 60 min were significantly higher. Body mass index was negatively correlated with insulin sensitivity (MI) and positively correlated with HOMA-β, a measurement of insulin secretion. CONCLUSIONS: We show that FDR are more likely to have impaired glucose tolerance and display higher OGTT plasma glucose and insulin, indicating an unfavorable metabolic profile. We conclude that OGTT is a simple and yet informative metabolic assessment in the FDR group. In both groups, we saw a negative correlation between body mass index and MI, confirming the role of body mass index in insulin resistance.
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spelling pubmed-55133472017-07-19 Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study Henninger, Josefin Rawshani, Araz Hammarstedt, Ann Eliasson, Björn BMC Endocr Disord Research Article BACKGROUND: Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and persons with no known family history of T2D (non-FDR). METHODS: In 200 FDR and 73 non-FDR, we compared anthropometrics, glucose tolerance status, different measurements of insulin secretion, insulin resistance, as well as blood lipids and other blood analyses. RESULTS: In the FDR group, 30 individuals had impaired glucose tolerance or T2D. Among the non-FDR, two individuals had impaired glucose tolerance. In unadjusted data, the FDR were older, had stronger heredity for coronary heart disease, lower body mass index and weight, higher OGTT plasma glucose concentrations, and impaired insulin secretion (all p < 0.05). Using propensity score, we matched the groups, resulting in significantly stronger heredity of coronary heart disease, higher OGTT plasma glucose at 60 and 90 min, larger glucose area under curve during the OGTT and higher serum creatinine among the FDR. Using least squares means, OGTT glucose at 60 and 120 min, as well as the area under curve, and OGTT insulin levels at 60 min were significantly higher. Body mass index was negatively correlated with insulin sensitivity (MI) and positively correlated with HOMA-β, a measurement of insulin secretion. CONCLUSIONS: We show that FDR are more likely to have impaired glucose tolerance and display higher OGTT plasma glucose and insulin, indicating an unfavorable metabolic profile. We conclude that OGTT is a simple and yet informative metabolic assessment in the FDR group. In both groups, we saw a negative correlation between body mass index and MI, confirming the role of body mass index in insulin resistance. BioMed Central 2017-07-14 /pmc/articles/PMC5513347/ /pubmed/28705209 http://dx.doi.org/10.1186/s12902-017-0191-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Henninger, Josefin
Rawshani, Araz
Hammarstedt, Ann
Eliasson, Björn
Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title_full Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title_fullStr Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title_full_unstemmed Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title_short Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
title_sort metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513347/
https://www.ncbi.nlm.nih.gov/pubmed/28705209
http://dx.doi.org/10.1186/s12902-017-0191-5
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