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Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity

OBJECTIVE: Endothelial dysfunction plays a pivotal role in the development of diabetic cardiovascular complications. Accumulation of endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity have been...

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Detalles Bibliográficos
Autores principales:	Lu, Chang-Wu, Lin, Yuan, Lei, Yan-Ping, Wang, Lan, He, Zhi-Min, Xiong, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513417/ https://www.ncbi.nlm.nih.gov/pubmed/28715444 http://dx.doi.org/10.1371/journal.pone.0179908

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