On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse trans...

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Detalles Bibliográficos
Autores principales: Silas, Sukrit, Makarova, Kira S., Shmakov, Sergey, Páez-Espino, David, Mohr, Georg, Liu, Yi, Davison, Michelle, Roux, Simon, Krishnamurthy, Siddharth R., Fu, Becky Xu Hua, Hansen, Loren L., Wang, David, Sullivan, Matthew B., Millard, Andrew, Clokie, Martha R., Bhaya, Devaki, Lambowitz, Alan M., Kyrpides, Nikos C., Koonin, Eugene V., Fire, Andrew Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513706/
https://www.ncbi.nlm.nih.gov/pubmed/28698278
http://dx.doi.org/10.1128/mBio.00897-17

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