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CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epigenetic mec...

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Detalles Bibliográficos
Autores principales:	Bryant, Jessica M., Regnault, Clément, Scheidig-Benatar, Christine, Baumgarten, Sebastian, Guizetti, Julien, Scherf, Artur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513710/ https://www.ncbi.nlm.nih.gov/pubmed/28698275 http://dx.doi.org/10.1128/mBio.00729-17

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