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Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report
Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513850/ https://www.ncbi.nlm.nih.gov/pubmed/28744164 http://dx.doi.org/10.2147/IMCRJ.S135643 |
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author | Kodliwadmath, Ashwin |
author_facet | Kodliwadmath, Ashwin |
author_sort | Kodliwadmath, Ashwin |
collection | PubMed |
description | Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock. |
format | Online Article Text |
id | pubmed-5513850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55138502017-07-25 Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report Kodliwadmath, Ashwin Int Med Case Rep J Case Report Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock. Dove Medical Press 2017-07-10 /pmc/articles/PMC5513850/ /pubmed/28744164 http://dx.doi.org/10.2147/IMCRJ.S135643 Text en © 2017 Kodliwadmath. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Kodliwadmath, Ashwin Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title | Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title_full | Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title_fullStr | Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title_full_unstemmed | Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title_short | Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report |
title_sort | phenytoin-induced stevens–johnson syndrome with myocarditis: a rare case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513850/ https://www.ncbi.nlm.nih.gov/pubmed/28744164 http://dx.doi.org/10.2147/IMCRJ.S135643 |
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