Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle

Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system for muscle contraction, in addition to calcium-mediated thin filament regulation. These two systems cooperate to generate force, but the exten...

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Detalles Bibliográficos
Autores principales: Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514028/
https://www.ncbi.nlm.nih.gov/pubmed/28717163
http://dx.doi.org/10.1038/s41598-017-05999-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514028/
https://www.ncbi.nlm.nih.gov/pubmed/28717163
http://dx.doi.org/10.1038/s41598-017-05999-2

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