Cargando…

Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle

Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system for muscle contraction, in addition to calcium-mediated thin filament regulation. These two systems cooperate to generate force, but the exten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marcucci, Lorenzo, Washio, Takumi, Yanagida, Toshio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514028/ https://www.ncbi.nlm.nih.gov/pubmed/28717163 http://dx.doi.org/10.1038/s41598-017-05999-2

Ejemplares similares

The positional stability of thick filaments in activated skeletal muscle depends on sarcomere length: evidence for the role of titin filaments
Publicado: (1987)

Proposed mechanism for the length dependence of the force developed in maximally activated muscles
por: Marcucci, Lorenzo, et al.
Publicado: (2019)

The giant protein titin regulates the length of the striated muscle thick filament
por: Tonino, Paola, et al.
Publicado: (2017)

Titin‐based mechanosensing modulates muscle hypertrophy
por: van der Pijl, Robbert, et al.
Publicado: (2018)

Roles of Titin in the Structure and Elasticity of the Sarcomere
por: Tskhovrebova, Larissa, et al.
Publicado: (2010)

Cytoskeletal protein kinases: titin and its relations in mechanosensing
por: Gautel, Mathias
Publicado: (2011)

Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force–length relationship
por: Schappacher-Tilp, Gudrun
Publicado: (2018)

Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling
por: Marcucci, Lorenzo, et al.
Publicado: (2016)

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice
por: Smart, Nicola, et al.
Publicado: (2017)

Sarcomere length–dependent effects on Ca(2+)-troponin regulation in myocardium expressing compliant titin
por: Li, King-Lun, et al.
Publicado: (2019)

Titin stiffness modifies the force-generating region of muscle sarcomeres
por: Li, Yong, et al.
Publicado: (2016)

Titin N2A Domain and Its Interactions at the Sarcomere
por: Adewale, Adeleye O., et al.
Publicado: (2021)

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing
por: Park-Holohan, So-Jin, et al.
Publicado: (2021)

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator
por: van der Pijl, Robbert J., et al.
Publicado: (2021)

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere
por: Bogomolovas, Julius, et al.
Publicado: (2021)

Titin isoform size is not correlated with thin filament length in rat skeletal muscle
por: Greaser, Marion L., et al.
Publicado: (2014)

Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
por: Rudolph, Franziska, et al.
Publicado: (2020)

Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development
por: Kötter, Sebastian, et al.
Publicado: (2022)

Differences in Effects of Length-Dependent Regulation of Force and Ca(2+) Transient in the Myocardial Trabeculae of the Rat Right Atrium and Ventricle
por: Lookin, Oleg, et al.
Publicado: (2023)

Flightin Is Essential for Thick Filament Assembly and Sarcomere Stability in Drosophila Flight Muscles
por: Reedy, Mary C., et al.
Publicado: (2000)

Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load
por: Ibata, Neil, et al.
Publicado: (2021)

Pressure overloaded right ventricles: importance of trabeculae in evaluation of RV function by CMR
por: Driessen, Mieke, et al.
Publicado: (2013)

The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler
por: Bennett, Pauline, et al.
Publicado: (2020)

Titin force in muscle cells alters lattice order, thick and thin filament protein formation
por: Hessel, Anthony L., et al.
Publicado: (2022)

M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere
por: Weinert, Stefanie, et al.
Publicado: (2006)

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres
por: da Silva Lopes, Katharina, et al.
Publicado: (2011)

Mechanism of contraction rhythm homeostasis for hyperthermal sarcomeric oscillations of neonatal cardiomyocytes
por: Shintani, Seine A., et al.
Publicado: (2020)

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function
por: Unger, Andreas, et al.
Publicado: (2017)

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation
por: Ahlberg, Gustav, et al.
Publicado: (2018)

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
por: Swist, Sandra, et al.
Publicado: (2020)

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins
por: Loreau, Vincent, et al.
Publicado: (2023)

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1
por: McElhinny, Abigail S., et al.
Publicado: (2002)

Approximation for Cooperative Interactions of a Spatially-Detailed Cardiac Sarcomere Model
por: Washio, Takumi, et al.
Publicado: (2011)

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
por: Bogomolovas, Julijus, et al.
Publicado: (2014)

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
por: Krysiak, Judith, et al.
Publicado: (2018)

Collective Cell Behavior in Mechanosensing of Substrate Thickness
por: Tusan, Camelia G., et al.
Publicado: (2018)

Mechanosensing in Myosin Filament Solves a 60 Years Old Conflict in Skeletal Muscle Modeling between High Power Output and Slow Rise in Tension
por: Marcucci, Lorenzo, et al.
Publicado: (2016)

In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle
por: Moo, Eng Kuan, et al.
Publicado: (2016)

The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line
Publicado: (1988)

A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy
por: Kuwabara, Yasuhide, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ulukk54helk4d38fcjlb24tnj7