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Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to the lengthy synthetic routes and the lack of structure-act...

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Detalles Bibliográficos
Autores principales:	Ng, Wai-Lung, Li, Ho-Chuen, Lau, Kit-Man, Chan, Anthony K. N., Lau, Clara Bik-San, Shing, Tony K. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514135/ https://www.ncbi.nlm.nih.gov/pubmed/28717146 http://dx.doi.org/10.1038/s41598-017-05895-9

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