Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting

Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex, while no interaction of Ku70 with integrase f...

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Detalles Bibliográficos
Autores principales: Anisenko, Andrey N., Knyazhanskaya, Ekaterina S., Zalevsky, Artur O., Agapkina, Julia Yu, Sizov, Aleksander I., Zatsepin, Timofey S., Gottikh, Marina B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514147/
https://www.ncbi.nlm.nih.gov/pubmed/28717247
http://dx.doi.org/10.1038/s41598-017-05659-5

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