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Microbial transformation of artemisinin by Aspergillus terreus

BACKGROUND: Artemisinin (1) and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbia...

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Detalles Bibliográficos
Autores principales: Yu, Hongchang, Zhu, Baowu, Zhan, Yulian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514170/
https://www.ncbi.nlm.nih.gov/pubmed/28775933
http://dx.doi.org/10.1186/s40643-017-0164-6
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author Yu, Hongchang
Zhu, Baowu
Zhan, Yulian
author_facet Yu, Hongchang
Zhu, Baowu
Zhan, Yulian
author_sort Yu, Hongchang
collection PubMed
description BACKGROUND: Artemisinin (1) and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbial transformation is a promising route to obtain artemisinin derivatives. The present study focuses on the microbial transformation of artemisinin by Aspergillus terreus. RESULTS: During 6 days at 28 °C and 180 rpm, Aspergillus terreus transformed artemisinin to two products. They were identified as 1-deoxyartemisinin (2) and 4α-hydroxy-1-deoxyartemisinin (3) on the basis of their spectroscopic data. CONCLUSIONS: The microbial transformation of artemisinin by Aspergillus terreus was investigated, and two products (1-deoxyartemisinin and 4α-hydroxy-1-deoxyartemisinin) were obtained. This study is the first to report on the microbial transformation of artemisinin by Aspergillus terreus.
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spelling pubmed-55141702017-08-01 Microbial transformation of artemisinin by Aspergillus terreus Yu, Hongchang Zhu, Baowu Zhan, Yulian Bioresour Bioprocess Research BACKGROUND: Artemisinin (1) and its derivatives are now being widely used as antimalarial drugs, and they also exhibited good antitumor activities. So there has been much interest in the structural modification of artemisinin and its derivatives because of their effective bioactivities. The microbial transformation is a promising route to obtain artemisinin derivatives. The present study focuses on the microbial transformation of artemisinin by Aspergillus terreus. RESULTS: During 6 days at 28 °C and 180 rpm, Aspergillus terreus transformed artemisinin to two products. They were identified as 1-deoxyartemisinin (2) and 4α-hydroxy-1-deoxyartemisinin (3) on the basis of their spectroscopic data. CONCLUSIONS: The microbial transformation of artemisinin by Aspergillus terreus was investigated, and two products (1-deoxyartemisinin and 4α-hydroxy-1-deoxyartemisinin) were obtained. This study is the first to report on the microbial transformation of artemisinin by Aspergillus terreus. Springer Berlin Heidelberg 2017-07-17 2017 /pmc/articles/PMC5514170/ /pubmed/28775933 http://dx.doi.org/10.1186/s40643-017-0164-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Yu, Hongchang
Zhu, Baowu
Zhan, Yulian
Microbial transformation of artemisinin by Aspergillus terreus
title Microbial transformation of artemisinin by Aspergillus terreus
title_full Microbial transformation of artemisinin by Aspergillus terreus
title_fullStr Microbial transformation of artemisinin by Aspergillus terreus
title_full_unstemmed Microbial transformation of artemisinin by Aspergillus terreus
title_short Microbial transformation of artemisinin by Aspergillus terreus
title_sort microbial transformation of artemisinin by aspergillus terreus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514170/
https://www.ncbi.nlm.nih.gov/pubmed/28775933
http://dx.doi.org/10.1186/s40643-017-0164-6
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