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Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer’s disease (AD), 47 with vascular...

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Autores principales: Bednarska-Makaruk, Małgorzata, Graban, Ałła, Wiśniewska, Anna, Łojkowska, Wanda, Bochyńska, Anna, Gugała-Iwaniuk, Magdalena, Sławińska, Ksenia, Ługowska, Agnieszka, Ryglewicz, Danuta, Wehr, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514216/
https://www.ncbi.nlm.nih.gov/pubmed/28421328
http://dx.doi.org/10.1007/s10522-017-9701-0
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author Bednarska-Makaruk, Małgorzata
Graban, Ałła
Wiśniewska, Anna
Łojkowska, Wanda
Bochyńska, Anna
Gugała-Iwaniuk, Magdalena
Sławińska, Ksenia
Ługowska, Agnieszka
Ryglewicz, Danuta
Wehr, Hanna
author_facet Bednarska-Makaruk, Małgorzata
Graban, Ałła
Wiśniewska, Anna
Łojkowska, Wanda
Bochyńska, Anna
Gugała-Iwaniuk, Magdalena
Sławińska, Ksenia
Ługowska, Agnieszka
Ryglewicz, Danuta
Wehr, Hanna
author_sort Bednarska-Makaruk, Małgorzata
collection PubMed
description The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer’s disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia.
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spelling pubmed-55142162017-08-01 Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia Bednarska-Makaruk, Małgorzata Graban, Ałła Wiśniewska, Anna Łojkowska, Wanda Bochyńska, Anna Gugała-Iwaniuk, Magdalena Sławińska, Ksenia Ługowska, Agnieszka Ryglewicz, Danuta Wehr, Hanna Biogerontology Research Article The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer’s disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia. Springer Netherlands 2017-04-18 2017 /pmc/articles/PMC5514216/ /pubmed/28421328 http://dx.doi.org/10.1007/s10522-017-9701-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Bednarska-Makaruk, Małgorzata
Graban, Ałła
Wiśniewska, Anna
Łojkowska, Wanda
Bochyńska, Anna
Gugała-Iwaniuk, Magdalena
Sławińska, Ksenia
Ługowska, Agnieszka
Ryglewicz, Danuta
Wehr, Hanna
Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title_full Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title_fullStr Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title_full_unstemmed Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title_short Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
title_sort association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514216/
https://www.ncbi.nlm.nih.gov/pubmed/28421328
http://dx.doi.org/10.1007/s10522-017-9701-0
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