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Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer

PURPOSE: Quality of life (QoL) outcomes play a major role in the treatment selection for prostate cancer (CaP). We evaluated the urinary QoL outcomes in men who were treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for CaP. METHODS AND MATERIALS: We enrolled men who were dia...

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Autores principales: Salami, Simpa S., Obedian, Edward, Zimberg, Shawn, Olsson, Carl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514226/
https://www.ncbi.nlm.nih.gov/pubmed/28740902
http://dx.doi.org/10.1016/j.adro.2016.10.005
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author Salami, Simpa S.
Obedian, Edward
Zimberg, Shawn
Olsson, Carl A.
author_facet Salami, Simpa S.
Obedian, Edward
Zimberg, Shawn
Olsson, Carl A.
author_sort Salami, Simpa S.
collection PubMed
description PURPOSE: Quality of life (QoL) outcomes play a major role in the treatment selection for prostate cancer (CaP). We evaluated the urinary QoL outcomes in men who were treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for CaP. METHODS AND MATERIALS: We enrolled men who were diagnosed with CaP and underwent IG-IMRT in a large urological group practice into a prospectively maintained database. The typical radiation treatment dosage to prostates and seminal vesicles was 8100 cGy in 45 fractions. Urinary QoL was self-assessed using the standardized incontinence grade and International Prostate Symptom Score (IPSS) at baseline and at each follow-up visit. We evaluated the cumulative incidence of urinary incontinence and changes in both continence and IPSS over time. RESULTS: Of the 3602 men who were eligible for analysis, 3086 (85.7%) had no urinary incontinence; 479 (13.3 %) had minimal incontinence (no requirement for pads), and 37 (1.0 %) had significant urinary incontinence that required the use of pads or interfered with activities of daily living, at baseline. After a median follow-up of 24 months (range: 12.0-41.0 months), these numbers were 80.6%, 17.4%, and 2.0%, respectively. Radiation therapy appeared to have a beneficial effect on some men: 54.1% of men with minimal incontinence became completely continent of urine during follow-up. Of those with significant urinary incontinence, 29.7% reported resolution and 27.0% reported improved symptoms with no requirement for pads. Of the 1276 men with moderate IPSS, the mean IPSS decreased from 12 to 9.8 at the time of the last follow-up (P < .001). Similarly, of the 233 men with severe IPSS, the mean IPSS decreased from 24 to 13 at the time of the last follow-up (P < .001). CONCLUSION: IG-IMRT for clinically localized CaP is associated with a relatively low incidence of urinary incontinence. Although unexplained, IG-IMRT seems to improve symptoms in some men with baseline urinary incontinence and moderate-to-severe IPSS.
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spelling pubmed-55142262017-07-24 Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer Salami, Simpa S. Obedian, Edward Zimberg, Shawn Olsson, Carl A. Adv Radiat Oncol Scientific Article PURPOSE: Quality of life (QoL) outcomes play a major role in the treatment selection for prostate cancer (CaP). We evaluated the urinary QoL outcomes in men who were treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for CaP. METHODS AND MATERIALS: We enrolled men who were diagnosed with CaP and underwent IG-IMRT in a large urological group practice into a prospectively maintained database. The typical radiation treatment dosage to prostates and seminal vesicles was 8100 cGy in 45 fractions. Urinary QoL was self-assessed using the standardized incontinence grade and International Prostate Symptom Score (IPSS) at baseline and at each follow-up visit. We evaluated the cumulative incidence of urinary incontinence and changes in both continence and IPSS over time. RESULTS: Of the 3602 men who were eligible for analysis, 3086 (85.7%) had no urinary incontinence; 479 (13.3 %) had minimal incontinence (no requirement for pads), and 37 (1.0 %) had significant urinary incontinence that required the use of pads or interfered with activities of daily living, at baseline. After a median follow-up of 24 months (range: 12.0-41.0 months), these numbers were 80.6%, 17.4%, and 2.0%, respectively. Radiation therapy appeared to have a beneficial effect on some men: 54.1% of men with minimal incontinence became completely continent of urine during follow-up. Of those with significant urinary incontinence, 29.7% reported resolution and 27.0% reported improved symptoms with no requirement for pads. Of the 1276 men with moderate IPSS, the mean IPSS decreased from 12 to 9.8 at the time of the last follow-up (P < .001). Similarly, of the 233 men with severe IPSS, the mean IPSS decreased from 24 to 13 at the time of the last follow-up (P < .001). CONCLUSION: IG-IMRT for clinically localized CaP is associated with a relatively low incidence of urinary incontinence. Although unexplained, IG-IMRT seems to improve symptoms in some men with baseline urinary incontinence and moderate-to-severe IPSS. Elsevier 2016-10-29 /pmc/articles/PMC5514226/ /pubmed/28740902 http://dx.doi.org/10.1016/j.adro.2016.10.005 Text en © 2016 The Authors on behalf of the American Society for Radiation Oncology http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Scientific Article
Salami, Simpa S.
Obedian, Edward
Zimberg, Shawn
Olsson, Carl A.
Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title_full Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title_fullStr Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title_full_unstemmed Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title_short Urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
title_sort urinary quality of life outcomes in men who were treated with image-guided intensity-modulated radiation therapy for prostate cancer
topic Scientific Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514226/
https://www.ncbi.nlm.nih.gov/pubmed/28740902
http://dx.doi.org/10.1016/j.adro.2016.10.005
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