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Patient-reported distress and survival among patients receiving definitive radiation therapy

OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT pat...

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Autores principales: Habboush, Yacob, Shannon, Robert P., Niazi, Shehzad K., Hollant, Laeticia, Single, Megan, Gaines, Katherine, Smart, Bridget, Chimato, Nicolette T., Heckman, Michael G., Buskirk, Steven J., Vallow, Laura A., Tzou, Katherine S., Ko, Stephen J., Peterson, Jennifer L., Biers, Heather A., Day, Atiya B., Nelson, Kimberly A., Sloan, Jeff A., Halyard, Michele Y., Miller, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514245/
https://www.ncbi.nlm.nih.gov/pubmed/28740934
http://dx.doi.org/10.1016/j.adro.2017.03.004
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author Habboush, Yacob
Shannon, Robert P.
Niazi, Shehzad K.
Hollant, Laeticia
Single, Megan
Gaines, Katherine
Smart, Bridget
Chimato, Nicolette T.
Heckman, Michael G.
Buskirk, Steven J.
Vallow, Laura A.
Tzou, Katherine S.
Ko, Stephen J.
Peterson, Jennifer L.
Biers, Heather A.
Day, Atiya B.
Nelson, Kimberly A.
Sloan, Jeff A.
Halyard, Michele Y.
Miller, Robert C.
author_facet Habboush, Yacob
Shannon, Robert P.
Niazi, Shehzad K.
Hollant, Laeticia
Single, Megan
Gaines, Katherine
Smart, Bridget
Chimato, Nicolette T.
Heckman, Michael G.
Buskirk, Steven J.
Vallow, Laura A.
Tzou, Katherine S.
Ko, Stephen J.
Peterson, Jennifer L.
Biers, Heather A.
Day, Atiya B.
Nelson, Kimberly A.
Sloan, Jeff A.
Halyard, Michele Y.
Miller, Robert C.
author_sort Habboush, Yacob
collection PubMed
description OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. METHODS AND MATERIALS: A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). RESULTS: As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” CONCLUSIONS: PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT.
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spelling pubmed-55142452017-07-24 Patient-reported distress and survival among patients receiving definitive radiation therapy Habboush, Yacob Shannon, Robert P. Niazi, Shehzad K. Hollant, Laeticia Single, Megan Gaines, Katherine Smart, Bridget Chimato, Nicolette T. Heckman, Michael G. Buskirk, Steven J. Vallow, Laura A. Tzou, Katherine S. Ko, Stephen J. Peterson, Jennifer L. Biers, Heather A. Day, Atiya B. Nelson, Kimberly A. Sloan, Jeff A. Halyard, Michele Y. Miller, Robert C. Adv Radiat Oncol Scientific Article OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. METHODS AND MATERIALS: A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress). Additionally, patients were asked to rate their overall distress level from 0 (no distress) to 10 (extreme distress). This overall distress level was our primary patient-reported distress measure and was examined as a continuous variable and as a categorical variable with 3 PRD levels (low, 0-3 [n = 295]; moderate, 4-6 [n = 222]; and high, 7-10 [n = 161]). RESULTS: As a continuous variable in multivariable Cox regression analysis, a higher overall PRD level was associated with poorer survival after RT (hazard ratio [HR], 1.39; P = .004). As a categorical variable, compared with patients with low distress, survival was poorer for patients with moderate distress (HR, 1.62; P = .038) or high distress (HR, 1.49; P = .12), but the latter difference was not significant. When the moderate and high distress levels were combined, survival was significantly poorer compared with the low distress level (HR, 1.57; P = .034). The top 5 specific causes of distress that patients mentioned were “How I feel during treatment,” “Fatigue,” “Out-of-pocket medical costs,” “Pain that affects my daily functioning,” and “Sleep difficulties.” CONCLUSIONS: PRD before or during RT is a prognostic factor associated with decreased survival. Distress screening guidelines and interventions should be implemented for patients receiving definitive RT. Elsevier 2017-03-20 /pmc/articles/PMC5514245/ /pubmed/28740934 http://dx.doi.org/10.1016/j.adro.2017.03.004 Text en © 2017 The Authors on behalf of the American Society for Radiation Oncology http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Scientific Article
Habboush, Yacob
Shannon, Robert P.
Niazi, Shehzad K.
Hollant, Laeticia
Single, Megan
Gaines, Katherine
Smart, Bridget
Chimato, Nicolette T.
Heckman, Michael G.
Buskirk, Steven J.
Vallow, Laura A.
Tzou, Katherine S.
Ko, Stephen J.
Peterson, Jennifer L.
Biers, Heather A.
Day, Atiya B.
Nelson, Kimberly A.
Sloan, Jeff A.
Halyard, Michele Y.
Miller, Robert C.
Patient-reported distress and survival among patients receiving definitive radiation therapy
title Patient-reported distress and survival among patients receiving definitive radiation therapy
title_full Patient-reported distress and survival among patients receiving definitive radiation therapy
title_fullStr Patient-reported distress and survival among patients receiving definitive radiation therapy
title_full_unstemmed Patient-reported distress and survival among patients receiving definitive radiation therapy
title_short Patient-reported distress and survival among patients receiving definitive radiation therapy
title_sort patient-reported distress and survival among patients receiving definitive radiation therapy
topic Scientific Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514245/
https://www.ncbi.nlm.nih.gov/pubmed/28740934
http://dx.doi.org/10.1016/j.adro.2017.03.004
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