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Are There Modifiable Risk Factors to Improve AKI?
Acute kidney injury (AKI) is a common critical syndrome, with high morbidity and mortality. Patients with AKI typically have an adverse prognosis, from incident chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), subsequent cardiovascular disease, and ultimately death. Howev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514336/ https://www.ncbi.nlm.nih.gov/pubmed/28744467 http://dx.doi.org/10.1155/2017/5605634 |
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author | Nie, Sasa Tang, Li Zhang, Weiguang Feng, Zhe Chen, Xiangmei |
author_facet | Nie, Sasa Tang, Li Zhang, Weiguang Feng, Zhe Chen, Xiangmei |
author_sort | Nie, Sasa |
collection | PubMed |
description | Acute kidney injury (AKI) is a common critical syndrome, with high morbidity and mortality. Patients with AKI typically have an adverse prognosis, from incident chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), subsequent cardiovascular disease, and ultimately death. However, there is currently no effective therapy for AKI. Early detection of risk factors for AKI may offer a good approach to prevention or early intervention. Traditional risk factors include extreme age, many common comorbid diseases, such as preexisting CKD, some specific exposures, such as sepsis, and exposure to some nephrotoxic agents. Recently, several novel risk factors for AKI, such as hyperuricemia, hypoalbuminemia, obesity, anemia, and hyperglycemia, have been identified. The underlying mechanisms between these nontraditional risk factors and AKI and whether their correction can reduce AKI occurrence remain to be clarified. This review describes the current epidemiology of AKI, summarizes its outcome, outlines the traditional risk profile, and finally highlights some recently identified novel risk factors. |
format | Online Article Text |
id | pubmed-5514336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55143362017-07-25 Are There Modifiable Risk Factors to Improve AKI? Nie, Sasa Tang, Li Zhang, Weiguang Feng, Zhe Chen, Xiangmei Biomed Res Int Review Article Acute kidney injury (AKI) is a common critical syndrome, with high morbidity and mortality. Patients with AKI typically have an adverse prognosis, from incident chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), subsequent cardiovascular disease, and ultimately death. However, there is currently no effective therapy for AKI. Early detection of risk factors for AKI may offer a good approach to prevention or early intervention. Traditional risk factors include extreme age, many common comorbid diseases, such as preexisting CKD, some specific exposures, such as sepsis, and exposure to some nephrotoxic agents. Recently, several novel risk factors for AKI, such as hyperuricemia, hypoalbuminemia, obesity, anemia, and hyperglycemia, have been identified. The underlying mechanisms between these nontraditional risk factors and AKI and whether their correction can reduce AKI occurrence remain to be clarified. This review describes the current epidemiology of AKI, summarizes its outcome, outlines the traditional risk profile, and finally highlights some recently identified novel risk factors. Hindawi 2017 2017-07-04 /pmc/articles/PMC5514336/ /pubmed/28744467 http://dx.doi.org/10.1155/2017/5605634 Text en Copyright © 2017 Sasa Nie et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nie, Sasa Tang, Li Zhang, Weiguang Feng, Zhe Chen, Xiangmei Are There Modifiable Risk Factors to Improve AKI? |
title | Are There Modifiable Risk Factors to Improve AKI? |
title_full | Are There Modifiable Risk Factors to Improve AKI? |
title_fullStr | Are There Modifiable Risk Factors to Improve AKI? |
title_full_unstemmed | Are There Modifiable Risk Factors to Improve AKI? |
title_short | Are There Modifiable Risk Factors to Improve AKI? |
title_sort | are there modifiable risk factors to improve aki? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514336/ https://www.ncbi.nlm.nih.gov/pubmed/28744467 http://dx.doi.org/10.1155/2017/5605634 |
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