A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation

Recent studies indicate important roles for SMAD4 in SMCs proliferation, extracellular matrix maintenance, and blood vessel remodeling. However, the genetic effects of SMAD4 in the pathogenesis of thoracic aortic aneurysm and dissection (TAAD) are still largely unknown. Here we identified a function...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Huang, Hao-Yue, Bian, Guang-Liang, Yu, Yun-Sheng, Ye, Wen-Xue, Hua, Fei, Chen, Yi-Huan, Shen, Zhen-Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514432/
https://www.ncbi.nlm.nih.gov/pubmed/28666732
http://dx.doi.org/10.1016/j.ebiom.2017.06.022

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