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Metabolic, autophagic, and mitophagic activities in cancer initiation and progression
Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chang Gung University
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514543/ https://www.ncbi.nlm.nih.gov/pubmed/27372165 http://dx.doi.org/10.1016/j.bj.2015.10.002 |
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author | Hjelmeland, Anita Zhang, Jianhua |
author_facet | Hjelmeland, Anita Zhang, Jianhua |
author_sort | Hjelmeland, Anita |
collection | PubMed |
description | Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species-induced damage to molecules and organelles. Redox regulation, metabolic plasticity, autophagy, and mitophagy play important and interactive roles in cancer hallmarks including sustained proliferation, activated invasion, and replicative immortality. However, the impact of these processes can differ depending on the signaling pathways altered in cancer, tumor type, tumor stage, and/or the differentiation state. Here, we highlight some of the representative studies on the impact of oxidative and nitrosative activities, mitochondrial bioenergetics, metabolism, and autophagy and mitophagy in the context of tumorigenesis. We discuss the implications of these processes for cellular activities in cancer for anti-cancer-based therapeutics. |
format | Online Article Text |
id | pubmed-5514543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Chang Gung University |
record_format | MEDLINE/PubMed |
spelling | pubmed-55145432017-07-18 Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Hjelmeland, Anita Zhang, Jianhua Biomed J Review Article Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species-induced damage to molecules and organelles. Redox regulation, metabolic plasticity, autophagy, and mitophagy play important and interactive roles in cancer hallmarks including sustained proliferation, activated invasion, and replicative immortality. However, the impact of these processes can differ depending on the signaling pathways altered in cancer, tumor type, tumor stage, and/or the differentiation state. Here, we highlight some of the representative studies on the impact of oxidative and nitrosative activities, mitochondrial bioenergetics, metabolism, and autophagy and mitophagy in the context of tumorigenesis. We discuss the implications of these processes for cellular activities in cancer for anti-cancer-based therapeutics. Chang Gung University 2016-04 2016-06-08 /pmc/articles/PMC5514543/ /pubmed/27372165 http://dx.doi.org/10.1016/j.bj.2015.10.002 Text en © 2016 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Hjelmeland, Anita Zhang, Jianhua Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title | Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title_full | Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title_fullStr | Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title_full_unstemmed | Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title_short | Metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
title_sort | metabolic, autophagic, and mitophagic activities in cancer initiation and progression |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514543/ https://www.ncbi.nlm.nih.gov/pubmed/27372165 http://dx.doi.org/10.1016/j.bj.2015.10.002 |
work_keys_str_mv | AT hjelmelandanita metabolicautophagicandmitophagicactivitiesincancerinitiationandprogression AT zhangjianhua metabolicautophagicandmitophagicactivitiesincancerinitiationandprogression |