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Tretinoin peel: a critical view

The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasona...

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Autores principales: Sumita, Juliana Mayumi, Leonardi, Gislaine Ricci, Bagatin, Ediléia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514577/
https://www.ncbi.nlm.nih.gov/pubmed/29186249
http://dx.doi.org/10.1590/abd1806-4841.201755325
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author Sumita, Juliana Mayumi
Leonardi, Gislaine Ricci
Bagatin, Ediléia
author_facet Sumita, Juliana Mayumi
Leonardi, Gislaine Ricci
Bagatin, Ediléia
author_sort Sumita, Juliana Mayumi
collection PubMed
description The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasonable methodology, although without a consistent scientific background and consensus. Topical tretinoin is used for the treatment of various dermatoses such as acne, melasma, scars, skin aging and non-melanoma skin cancer. The identification of retinoids cellular receptors was reported in 1987, but a direct cause-effect relation has not been established. This article reviews studies evaluating the use of topical tretinoin as agent for superficial chemical peel. Most of them have shown benefits in the treatment of melasma and skin aging. A better quality methodology in the study design, considering indication and intervention is indispensable regarding concentration, vehicle and treatment regimen (interval and number of applications). Additionally, more controlled and randomized studies comparing the treatment with tretinoin cream versus its use as a peeling agent, mainly for melasma and photoaging, are necessary.
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spelling pubmed-55145772017-07-24 Tretinoin peel: a critical view Sumita, Juliana Mayumi Leonardi, Gislaine Ricci Bagatin, Ediléia An Bras Dermatol Review The tretinoin peel, also known as retinoic acid peel, is a superficial peeling often performed in dermatological clinics in Brazil. The first study on this was published in 2001, by Cuce et al., as a treatment option for melasma. Since then, other studies have reported its applicability with reasonable methodology, although without a consistent scientific background and consensus. Topical tretinoin is used for the treatment of various dermatoses such as acne, melasma, scars, skin aging and non-melanoma skin cancer. The identification of retinoids cellular receptors was reported in 1987, but a direct cause-effect relation has not been established. This article reviews studies evaluating the use of topical tretinoin as agent for superficial chemical peel. Most of them have shown benefits in the treatment of melasma and skin aging. A better quality methodology in the study design, considering indication and intervention is indispensable regarding concentration, vehicle and treatment regimen (interval and number of applications). Additionally, more controlled and randomized studies comparing the treatment with tretinoin cream versus its use as a peeling agent, mainly for melasma and photoaging, are necessary. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5514577/ /pubmed/29186249 http://dx.doi.org/10.1590/abd1806-4841.201755325 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Review
Sumita, Juliana Mayumi
Leonardi, Gislaine Ricci
Bagatin, Ediléia
Tretinoin peel: a critical view
title Tretinoin peel: a critical view
title_full Tretinoin peel: a critical view
title_fullStr Tretinoin peel: a critical view
title_full_unstemmed Tretinoin peel: a critical view
title_short Tretinoin peel: a critical view
title_sort tretinoin peel: a critical view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514577/
https://www.ncbi.nlm.nih.gov/pubmed/29186249
http://dx.doi.org/10.1590/abd1806-4841.201755325
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