Cargando…

An overview about oxidation in clinical practice of skin aging

Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider...

Descripción completa

Detalles Bibliográficos
Autores principales: Silva, Silas Arandas Monteiro e, Michniak-Kohn, Bozena, Leonardi, Gislaine Ricci
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514578/
https://www.ncbi.nlm.nih.gov/pubmed/29186250
http://dx.doi.org/10.1590/abd1806-4841.20175481
_version_ 1783250863457828864
author Silva, Silas Arandas Monteiro e
Michniak-Kohn, Bozena
Leonardi, Gislaine Ricci
author_facet Silva, Silas Arandas Monteiro e
Michniak-Kohn, Bozena
Leonardi, Gislaine Ricci
author_sort Silva, Silas Arandas Monteiro e
collection PubMed
description Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.
format Online
Article
Text
id pubmed-5514578
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Sociedade Brasileira de Dermatologia
record_format MEDLINE/PubMed
spelling pubmed-55145782017-07-24 An overview about oxidation in clinical practice of skin aging Silva, Silas Arandas Monteiro e Michniak-Kohn, Bozena Leonardi, Gislaine Ricci An Bras Dermatol Review Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect. Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5514578/ /pubmed/29186250 http://dx.doi.org/10.1590/abd1806-4841.20175481 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Review
Silva, Silas Arandas Monteiro e
Michniak-Kohn, Bozena
Leonardi, Gislaine Ricci
An overview about oxidation in clinical practice of skin aging
title An overview about oxidation in clinical practice of skin aging
title_full An overview about oxidation in clinical practice of skin aging
title_fullStr An overview about oxidation in clinical practice of skin aging
title_full_unstemmed An overview about oxidation in clinical practice of skin aging
title_short An overview about oxidation in clinical practice of skin aging
title_sort overview about oxidation in clinical practice of skin aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514578/
https://www.ncbi.nlm.nih.gov/pubmed/29186250
http://dx.doi.org/10.1590/abd1806-4841.20175481
work_keys_str_mv AT silvasilasarandasmonteiroe anoverviewaboutoxidationinclinicalpracticeofskinaging
AT michniakkohnbozena anoverviewaboutoxidationinclinicalpracticeofskinaging
AT leonardigislainericci anoverviewaboutoxidationinclinicalpracticeofskinaging
AT silvasilasarandasmonteiroe overviewaboutoxidationinclinicalpracticeofskinaging
AT michniakkohnbozena overviewaboutoxidationinclinicalpracticeofskinaging
AT leonardigislainericci overviewaboutoxidationinclinicalpracticeofskinaging