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Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery

BACKGROUND: Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. PATIENTS AND METHODS: 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriov...

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Autores principales: Harat, Maciej, Lebioda, Andrzej, Lasota, Judyta, Makarewicz, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514653/
https://www.ncbi.nlm.nih.gov/pubmed/28740448
http://dx.doi.org/10.1515/raon-2017-0018
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author Harat, Maciej
Lebioda, Andrzej
Lasota, Judyta
Makarewicz, Roman
author_facet Harat, Maciej
Lebioda, Andrzej
Lasota, Judyta
Makarewicz, Roman
author_sort Harat, Maciej
collection PubMed
description BACKGROUND: Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. PATIENTS AND METHODS: 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriovenous malformations, 38 (35%) with meningiomas, 16 (15%) with metastatic tumors, 16 (15%) with acoustic neuromas, 3 with (3%) cavernomas, and 2 (2%) each with anaplastic astrocytomas and anaplastic oligoastrocytomas. Edema area was delineated in MRI T2-FLAIR sequences 0, 6, 12, 18, 24, 30, and 38 months after treatment. Lesion location was defined as either above (n = 80) or below (n = 32) the “Frankfurt modified line” (FML). RESULTS: 17% of patients developed or had worsening post-treatment edema. Edema volume was maximal at 6 months (mean 7.2, SD 1.2) post radiosurgery. Post-SRS edema was 5.1 (1.06 – 24.53) times more likely in patients with lesions above the FML. There was no association between edema development and age, PTV size, number of beams, and diagnosis (p = 0.07). CONCLUSIONS: Radiosurgery-associated edema develops within 6 months of treatment and decreases over time. Edema occurrence is strongly related to lesion location, and its presence is much more likely when the treated lesions are situated above the Frankfurt line.
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spelling pubmed-55146532017-07-24 Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery Harat, Maciej Lebioda, Andrzej Lasota, Judyta Makarewicz, Roman Radiol Oncol Research Article BACKGROUND: Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. PATIENTS AND METHODS: 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriovenous malformations, 38 (35%) with meningiomas, 16 (15%) with metastatic tumors, 16 (15%) with acoustic neuromas, 3 with (3%) cavernomas, and 2 (2%) each with anaplastic astrocytomas and anaplastic oligoastrocytomas. Edema area was delineated in MRI T2-FLAIR sequences 0, 6, 12, 18, 24, 30, and 38 months after treatment. Lesion location was defined as either above (n = 80) or below (n = 32) the “Frankfurt modified line” (FML). RESULTS: 17% of patients developed or had worsening post-treatment edema. Edema volume was maximal at 6 months (mean 7.2, SD 1.2) post radiosurgery. Post-SRS edema was 5.1 (1.06 – 24.53) times more likely in patients with lesions above the FML. There was no association between edema development and age, PTV size, number of beams, and diagnosis (p = 0.07). CONCLUSIONS: Radiosurgery-associated edema develops within 6 months of treatment and decreases over time. Edema occurrence is strongly related to lesion location, and its presence is much more likely when the treated lesions are situated above the Frankfurt line. De Gruyter Open 2017-04-12 /pmc/articles/PMC5514653/ /pubmed/28740448 http://dx.doi.org/10.1515/raon-2017-0018 Text en © 2017 Radiol Oncol
spellingShingle Research Article
Harat, Maciej
Lebioda, Andrzej
Lasota, Judyta
Makarewicz, Roman
Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title_full Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title_fullStr Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title_full_unstemmed Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title_short Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery
title_sort evaluation of brain edema formation defined by mri after linac-based stereotactic radiosurgery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514653/
https://www.ncbi.nlm.nih.gov/pubmed/28740448
http://dx.doi.org/10.1515/raon-2017-0018
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