Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B(12), and Folic Acid in Patients with Premature Canities

BACKGROUND: Premature canities is a common yet unfathomed disorder. The evidence for the role of micronutrient deficiency in premature canities is not well established. AIM: The present study was undertaken to evaluate the micronutrient levels in Indian patients with premature canities as compared to controls. MATERIALS AND METHODS: We conducted a case–control study in 52 self-reporting patients with premature canities (<20 years age). Micronutrient levels including serum Vitamin B(12), biotin, and folic acid were assessed and compared among the patients and controls. RESULTS: We observed that mean serum Vitamin B(12) (198.07 ± 88.98 pg/ml in cases vs. 343.07 ± 143.06 pg/ml in controls, P = 0.000), folic acid (6.22 ± 2.46 ng/ml in cases vs. 8.49 ± 4.18 ng/ml in controls, P = 0.01), and biotin (252.71 ± 18.79 pg/ml in cases vs. 266.47 ± 30.44 pg/ml in controls, P = 0.013) levels were significantly lower in cases as compared to the controls. CONCLUSION: In view of the dark hair and many prevailing myths, premature canities is a significant problem in Asians with profound psychosocial impact. This study unveils the association with Vitamin B(12), folic acid, and biotin deficiencies. Larger studies are recommended to arrive on a logical conclusion.