Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis

Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmaph...

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Detalles Bibliográficos
Autores principales: Vankalakunti, M., Nada, R., Kumar, A., Patro, K., Ramakrishnan, S., Rangarajan, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514834/
https://www.ncbi.nlm.nih.gov/pubmed/28761240
http://dx.doi.org/10.4103/ijn.IJN_113_16
Descripción
Sumario:Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis.

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