Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis

Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmaph...

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Autores principales: Vankalakunti, M., Nada, R., Kumar, A., Patro, K., Ramakrishnan, S., Rangarajan, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514834/
https://www.ncbi.nlm.nih.gov/pubmed/28761240
http://dx.doi.org/10.4103/ijn.IJN_113_16
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author Vankalakunti, M.
Nada, R.
Kumar, A.
Patro, K.
Ramakrishnan, S.
Rangarajan, D.
author_facet Vankalakunti, M.
Nada, R.
Kumar, A.
Patro, K.
Ramakrishnan, S.
Rangarajan, D.
author_sort Vankalakunti, M.
collection PubMed
description Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis.
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spelling pubmed-55148342017-07-31 Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis Vankalakunti, M. Nada, R. Kumar, A. Patro, K. Ramakrishnan, S. Rangarajan, D. Indian J Nephrol Case Report Anti-glomerular basement membrane (GBM) antibody disease is a rare but well-characterized cause of glomerulonephritis. Patients present with rapidly progressive renal failure with hemoptysis. Early diagnosis is crucial in salvaging the renal damage and life-threatening pulmonary hemorrhage. Plasmapheresis and immunosuppression is the mode of therapy. Anti-GBM antibodies are polyclonal in nature. However, rare monoclonal antibodies can cause similar destruction of glomerular capillary walls. We describe distinct combination of circulating monoclonal and anti-GBM nephritis. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5514834/ /pubmed/28761240 http://dx.doi.org/10.4103/ijn.IJN_113_16 Text en Copyright: © 2017 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Vankalakunti, M.
Nada, R.
Kumar, A.
Patro, K.
Ramakrishnan, S.
Rangarajan, D.
Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title_full Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title_fullStr Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title_full_unstemmed Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title_short Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
title_sort circulating monoclonal igg1-kappa antibodies causing anti-glomerular basement membrane nephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514834/
https://www.ncbi.nlm.nih.gov/pubmed/28761240
http://dx.doi.org/10.4103/ijn.IJN_113_16
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