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Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDN...

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Autores principales: Angelova, Angelina, Angelov, Borislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514857/
https://www.ncbi.nlm.nih.gov/pubmed/28761415
http://dx.doi.org/10.4103/1673-5374.208546
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author Angelova, Angelina
Angelov, Borislav
author_facet Angelova, Angelina
Angelov, Borislav
author_sort Angelova, Angelina
collection PubMed
description Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB (cAMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at (i) neurotrophic protein regulation in the central and peripheral nervous systems, and (ii) diminishment of the production of reactive oxygen species (ROS) and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines.
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spelling pubmed-55148572017-07-31 Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair Angelova, Angelina Angelov, Borislav Neural Regen Res Invited Review Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB (cAMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at (i) neurotrophic protein regulation in the central and peripheral nervous systems, and (ii) diminishment of the production of reactive oxygen species (ROS) and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines. Medknow Publications & Media Pvt Ltd 2017-06 /pmc/articles/PMC5514857/ /pubmed/28761415 http://dx.doi.org/10.4103/1673-5374.208546 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Angelova, Angelina
Angelov, Borislav
Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title_full Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title_fullStr Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title_full_unstemmed Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title_short Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
title_sort dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514857/
https://www.ncbi.nlm.nih.gov/pubmed/28761415
http://dx.doi.org/10.4103/1673-5374.208546
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