RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells

Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) is the first example of targeted therapy. In fact, the oncogenic fusion-protein (PML-RAR) typical of this leukemia contains the retinoid-nuclear-receptor RARα. PML-RAR is responsible for the differentiation block of...

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Detalles Bibliográficos
Autores principales: Gianni, Maurizio, Fratelli, Maddalena, Bolis, Marco, Kurosaki, Mami, Zanetti, Adriana, Paroni, Gabriela, Rambaldi, Alessandro, Borleri, Gianmaria, Rochette-Egly, Cecile, Terao, Mineko, Garattini, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514891/
https://www.ncbi.nlm.nih.gov/pubmed/27419624
http://dx.doi.org/10.18632/oncotarget.10556

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