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Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages

BACKGROUND: The association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation. RESULTS: Six case-co...

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Autores principales: Huang, Wei, Song, Juan, Jia, Xiao-Wei, Chen, Yin-Xue, Shi, Jia, Jiang, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514904/
https://www.ncbi.nlm.nih.gov/pubmed/28410223
http://dx.doi.org/10.18632/oncotarget.16660
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author Huang, Wei
Song, Juan
Jia, Xiao-Wei
Chen, Yin-Xue
Shi, Jia
Jiang, Xun
author_facet Huang, Wei
Song, Juan
Jia, Xiao-Wei
Chen, Yin-Xue
Shi, Jia
Jiang, Xun
author_sort Huang, Wei
collection PubMed
description BACKGROUND: The association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation. RESULTS: Six case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30–2.04), 3.17 (2.11–4.76), 1.63 (1.17–2.26), 1.73 (1.25–2.39), and 2.73 (1.82–4.09), respectively]. The subgroup analyses all obtained similar results with overall populations. The results of clinical stages yielded a non-significant association. No publication bias was detected. MATERIALS AND METHODS: The PubMed and Chinese National Knowledge Infrastructure databases were searched up to December 27, 2016. Two authors independently selected studies, extracted and analyzed the data using the RevMan 5 software. Either a fixed effect or a random effect model was used to estimate pooled odds ratio and its 95% confidence intervals. CONCLUSIONS: We concluded that interleukin-10 rs1800896 polymorphism was significantly associated with head and neck cancer risk but not with the clinical stages thereof.
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spelling pubmed-55149042017-07-24 Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages Huang, Wei Song, Juan Jia, Xiao-Wei Chen, Yin-Xue Shi, Jia Jiang, Xun Oncotarget Research Paper BACKGROUND: The association of interleukin-10 rs1800896 polymorphism with head and neck cancer risk and its clinical stages has been investigated by many published studies, but the results remain inconsistent. Therefore, we conducted this meta-analysis for further investigation. RESULTS: Six case-control studies involving 1,781 head and neck cancer patients and 1,978 controls were yielded. The results indicated an association between rs1800896 polymorphism and increased head and neck risk [odds ratio (95%confidence interval) for G vs. A, GA vs. AA, GG vs. AA, GA+GG vs. AA, and GG vs. AA + GA were 1.63 (1.30–2.04), 3.17 (2.11–4.76), 1.63 (1.17–2.26), 1.73 (1.25–2.39), and 2.73 (1.82–4.09), respectively]. The subgroup analyses all obtained similar results with overall populations. The results of clinical stages yielded a non-significant association. No publication bias was detected. MATERIALS AND METHODS: The PubMed and Chinese National Knowledge Infrastructure databases were searched up to December 27, 2016. Two authors independently selected studies, extracted and analyzed the data using the RevMan 5 software. Either a fixed effect or a random effect model was used to estimate pooled odds ratio and its 95% confidence intervals. CONCLUSIONS: We concluded that interleukin-10 rs1800896 polymorphism was significantly associated with head and neck cancer risk but not with the clinical stages thereof. Impact Journals LLC 2017-03-29 /pmc/articles/PMC5514904/ /pubmed/28410223 http://dx.doi.org/10.18632/oncotarget.16660 Text en Copyright: © 2017 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Huang, Wei
Song, Juan
Jia, Xiao-Wei
Chen, Yin-Xue
Shi, Jia
Jiang, Xun
Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title_full Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title_fullStr Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title_full_unstemmed Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title_short Interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
title_sort interleukin-10 rs1800896 polymorphism is associated with increased head and neck cancer risk but not associated with its clinical stages
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514904/
https://www.ncbi.nlm.nih.gov/pubmed/28410223
http://dx.doi.org/10.18632/oncotarget.16660
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