The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo

Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increa...

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Detalles Bibliográficos
Autores principales: Scialdone, Annarita, Hasni, Muhammad Sharif, Damm, Jesper Kofoed, Lennartsson, Andreas, Gullberg, Urban, Drott, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514918/
https://www.ncbi.nlm.nih.gov/pubmed/28445158
http://dx.doi.org/10.18632/oncotarget.16964

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