Cargando…
Folic acid phenotype (FAP) is a superior biomarker predicting response to pemetrexed-based chemotherapy in malignant pleural mesothelioma
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare tumor linked to a dismal prognosis. Even the most effective chemotherapeutical regime of pemetrexed combined with cisplatin leads to a remission-rate of only about 40%. The reasons for the rather poor efficacy remain largely unknown. RESULTS...
Autores principales: | Mairinger, Fabian Dominik, Vollbrecht, Claudia, Flom, Elena, Christoph, Daniel Christian, Schmid, Kurt-Werner, Kollmeier, Jens, Popper, Helmut Hans, Mairinger, Thomas, Henry Walter, Robert Fred |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514925/ https://www.ncbi.nlm.nih.gov/pubmed/28415584 http://dx.doi.org/10.18632/oncotarget.16398 |
Ejemplares similares
-
microRNAs are differentially regulated between MDM2-positive and negative malignant pleural mesothelioma
por: Walter, Robert Fred Henry, et al.
Publicado: (2016) -
Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma
por: Walter, Robert Fred Henry, et al.
Publicado: (2019) -
Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy
por: Walter, Robert Fred Henry, et al.
Publicado: (2016) -
MDM2 is an important prognostic and predictive factor for
platin–pemetrexed therapy in malignant pleural mesotheliomas and
deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to
an MDM2-driven inactivation of P53
por: Walter, R F H, et al.
Publicado: (2015) -
Immunohistochemically detectable metallothionein expression in malignant pleural mesotheliomas is strongly associated with early failure to platin-based chemotherapy
por: Mairinger, Fabian D., et al.
Publicado: (2018)