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Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1
Cohesin is a multi-protein complex that tethers sister chromatids during mitosis and mediates DNA repair, genome compartmentalisation and regulation of gene expression. Cohesin subunits frequently acquire cancer loss-of-function alterations and act as tumour suppressors in several tumour types. This...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514935/ https://www.ncbi.nlm.nih.gov/pubmed/28430577 http://dx.doi.org/10.18632/oncotarget.16838 |