Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency

Arginine starvation has the potential to selectively treat both primary tumor and (micro) metastatic tissue with very low side effects. Arginine deiminase (ADI; EC 3.5.3.6), an arginine-degrading enzyme, has been studied as a potential anti-tumor drug for the treatment of arginine-auxotrophic tumors...

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Detalles Bibliográficos
Autores principales: Jiang, Hui, Guo, Song, Xiao, Dan, Bian, Xuzhao, Wang, Jie, Wang, Ying, Zhou, Huiting, Cai, Jun, Zheng, Zhongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514941/
https://www.ncbi.nlm.nih.gov/pubmed/28455966
http://dx.doi.org/10.18632/oncotarget.17032

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