Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis

The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, wi...

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Autores principales: Lu, Yingying, Li, Bingjue, Shen, Qixia, Wang, Rending, Chen, Zhimin, Jiang, Hong, Chen, Jianghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514963/
https://www.ncbi.nlm.nih.gov/pubmed/28415773
http://dx.doi.org/10.18632/oncotarget.16229
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author Lu, Yingying
Li, Bingjue
Shen, Qixia
Wang, Rending
Chen, Zhimin
Jiang, Hong
Chen, Jianghua
author_facet Lu, Yingying
Li, Bingjue
Shen, Qixia
Wang, Rending
Chen, Zhimin
Jiang, Hong
Chen, Jianghua
author_sort Lu, Yingying
collection PubMed
description The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, with 200 patients, were included. The presence of CD20+ B cells in renal biopsies during allograft rejection was associated with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive staining of the peritubular capillaries in renal biopsies was found in the analysis of patients who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was associated with an increased risk of graft loss and steroid resistance.
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spelling pubmed-55149632017-07-24 Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis Lu, Yingying Li, Bingjue Shen, Qixia Wang, Rending Chen, Zhimin Jiang, Hong Chen, Jianghua Oncotarget Review The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, with 200 patients, were included. The presence of CD20+ B cells in renal biopsies during allograft rejection was associated with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive staining of the peritubular capillaries in renal biopsies was found in the analysis of patients who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was associated with an increased risk of graft loss and steroid resistance. Impact Journals LLC 2017-03-15 /pmc/articles/PMC5514963/ /pubmed/28415773 http://dx.doi.org/10.18632/oncotarget.16229 Text en Copyright: © 2017 Lu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Lu, Yingying
Li, Bingjue
Shen, Qixia
Wang, Rending
Chen, Zhimin
Jiang, Hong
Chen, Jianghua
Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title_full Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title_fullStr Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title_full_unstemmed Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title_short Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
title_sort effects of cd20+ b-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514963/
https://www.ncbi.nlm.nih.gov/pubmed/28415773
http://dx.doi.org/10.18632/oncotarget.16229
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