Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target

Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of nume...

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Detalles Bibliográficos
Autores principales: Wen, Yiping, Cai, Jing, Hou, Yaya, Huang, Zaiju, Wang, Zehua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514966/
https://www.ncbi.nlm.nih.gov/pubmed/28415635
http://dx.doi.org/10.18632/oncotarget.16467
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author Wen, Yiping
Cai, Jing
Hou, Yaya
Huang, Zaiju
Wang, Zehua
author_facet Wen, Yiping
Cai, Jing
Hou, Yaya
Huang, Zaiju
Wang, Zehua
author_sort Wen, Yiping
collection PubMed
description Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. Here, we review up-to-date information regarding EZH2 expression patterns, functions, and molecular mechanisms in cancer stem cells in various malignant tumors and discuss the therapeutic potential of targeting EZH2 in tumors.
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spelling pubmed-55149662017-07-24 Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target Wen, Yiping Cai, Jing Hou, Yaya Huang, Zaiju Wang, Zehua Oncotarget Review Epigenetic modifications in cancer stem cells largely result in phenotypic and functional heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of Polycomb repressor complex 2, is highly expressed in cancer stem cells of numerous malignant tumors and has a critical function in cancer stem cell expansion and maintenance. Here, we review up-to-date information regarding EZH2 expression patterns, functions, and molecular mechanisms in cancer stem cells in various malignant tumors and discuss the therapeutic potential of targeting EZH2 in tumors. Impact Journals LLC 2017-03-22 /pmc/articles/PMC5514966/ /pubmed/28415635 http://dx.doi.org/10.18632/oncotarget.16467 Text en Copyright: © 2017 Wen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wen, Yiping
Cai, Jing
Hou, Yaya
Huang, Zaiju
Wang, Zehua
Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title_full Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title_fullStr Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title_full_unstemmed Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title_short Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target
title_sort role of ezh2 in cancer stem cells: from biological insight to a therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514966/
https://www.ncbi.nlm.nih.gov/pubmed/28415635
http://dx.doi.org/10.18632/oncotarget.16467
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