Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder that causes systemic accelerated aging in children. This syndrome is due to a mutation in the LMNA gene that leads to the production of a truncated and toxic form of lamin A called progerin. Because the balance between the A-type...

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Detalles Bibliográficos
Autores principales: Egesipe, Anne-Laure, Blondel, Sophie, Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Navarro, Claire, Sandre-Giovannoli, Annachiara De, Levy, Nicolas, Peschanski, Marc, Nissan, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515002/
https://www.ncbi.nlm.nih.gov/pubmed/28721276
http://dx.doi.org/10.1038/npjamd.2016.26

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